Cell and Tissue Engineering Laboratory – Arrigoni, Chiara

CELL AND TISSUE ENGINEERING LABORATORY

Director: Dr. Matteo Moretti

Chiara Arrigoni, Ph.D.

Bio

Chiara Arrigoni is currently a Post-doctoral Researcher at the Cell and Tissue Engineering Lab and at the Regenerative Medicine Technologies Laboratory, EOC (Lugano – Switzerland). She received her Master degree in biomedical engineering and her Ph.D. in bioengineering at Politecnico di Milano, with a period as a visiting Ph.D. student the Laboratoire de Biomatériaux et Bioingégnerie, Universitè Laval, Quebec, CA. During her post-doc at Mario Negri Institute of Pharmacological Research, under the supervision of prof. Andrea Remuzzi, she worked in the field of vascular tissue engineering, designing and exploiting flow perfusion bioreactors. Her main research focus is the engineering of vascularized musculoskeletal tissues at different scales, to be used either as tissue substitutes or as innovative 3D in vitro models. In particular, she investigates the role of vascularized microenvironment in the mechanisms underlying the metastatic processes.

Publications

 

Arrigoni C, Gilardi M, Bersini S, Candrian C, Moretti M. Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases. Stem Cell Rev. 2017 Jun;13(3):407-417.

Talò G, Turrisi C, Arrigoni C, Recordati C, Gerges I, Tamplenizza M, Cappelluti A, Riboldi SA, Moretti M. Industrialization of a perfusion bioreactor: prime example of a non-straightforward process. J Tissue Eng Regen Med. 2017 May 16.

Enomoto J, Kageyama T, Osaki T, Bonalumi F, Marchese F, Gautieri A, Bianchi E, Dubini G, Arrigoni C, Moretti M, Fukuda J. Catch-and-Release of Target Cells Using Aptamer-Conjugated Electroactive Zwitterionic Oligopeptide SAM. Sci Rep. 2017 Mar 7;7:43375.

Arrigoni C, Bersini S, Gilardi M, Moretti M. In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone. Int J Mol Sci. 2016 Aug 25;17(9). pii: E1405.

Arrigoni C, Bongio M, Talò G, Bersini S, Enomoto J, Fukuda J, Moretti M. Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels. Adv Healthc Mater. 2016 Jul;5(13):1617-26.

Bersini S, Arrigoni C, Lopa S, Bongio M, Martin I, Moretti M. Engineered miniaturized models of musculoskeletal diseases. Drug Discov Today. 2016 Sep;21(9):1429-36.

Bersini S, Gilardi M, Arrigoni C, Talò G, Zamai M, Zagra L, Caiolfa V, Moretti M. Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials. 2016 Jan;76:157-72.

Arrigoni C, De Luca P, Gilardi M, Previdi S, Broggini M, Moretti M. Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases. Mol Cancer. 2014 Oct 21;13:238.

Bersini S, Jeon JS, Dubini G, Arrigoni C, Chung S, Charest JL, Moretti M, Kamm RD. A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials. 2014 Mar;35(8):2454-61.

Arrigoni C, Chittò A, Mantero S, Remuzzi A. Rotating versus perfusion bioreactor for the culture of engineered vascular constructs based on hyaluronic acid. Biotechnol Bioeng. 2008 Aug 1;100(5):988-97.