CELL AND TISSUE ENGINEERING LABORATORY
Director: Dr. Matteo Moretti
Marta Bottagisio, Ph.D.
Bio
Marta Bottagisio received her Master’s Degree in Veterinary Biotechnology Sciences at the University of Milan (Italy) in 2014. From 2014 to the present, she works as Ph.D. candidate in Veterinary and Animal Science at the Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopedic Institute of Milan (Italy). She has recently completed her Ph.D. project focused on orthopedic infection characterized by the presence of bacterial biofilm on the surface of implants. She is also involved in several research projects on the evaluation of translational approaches in regenerative medicine in the musculoskeletal field.
In 2017, she spent six months at the Medical Biofilm Laboratory at the Center for Biofilm Engineering, Bozeman, Montana (USA) to learn and to apply validated dynamic microbiological culture techniques to obtain biofilm in vitro. Her research is now focused on the application of proteomic analyses to identify novel therapeutic targets or diagnostic biomarkers to detect late or chronic infection associated with the presence of biofilm on orthopedic medical devices. In March 2018, she will defend her Ph.D. dissertation entitled “Preclinical and proteomic evaluation of a Staphylococcus epidermidis clinical isolate in orthopedic biofilm-related infections.”
Publications
Bottagisio M, Soggiu A, Lovati AB, Toscano M, Piras C, Romanò CL, Bonizzi L, Roncada P, Drago L. Draft Genome Sequence of Staphylococcus epidermidis Clinical Strain GOI1153754-03-14 Isolated from an Infected Knee Prosthesis. Genome Announc. 2017 May 18;5(20). pii: e00378-17.
Lovati AB, Bottagisio M, de Vecchi E, Gallazzi E, Drago L. Animal Models of Implant-Related Low-Grade Infections. A Twenty-Year Review. Adv Exp Med Biol. 2017;971:29-50.
Lovati AB, Drago L, Bottagisio M, Bongio M, Ferrario M, Perego S, Sansoni V, De Vecchi E, Romanò CL. Systemic and Local Administration of Antimicrobial and Cell Therapies to Prevent Methicillin-Resistant Staphylococcus epidermidis-Induced Femoral Nonunions in a Rat Model. Mediators Inflamm. 2016;2016:9595706.
Lovati AB, Romanò CL, Bottagisio M, Monti L, De Vecchi E, Previdi S, Accetta R, Drago L. Modeling Staphylococcus epidermidis-Induced Non-Unions: Subclinical and Clinical Evidence in Rats. PLoS One. 2016 Jan 21;11(1):e0147447.
De Vecchi E, Bottagisio M, Bortolin M, Toscano M, Lovati AB, Drago L. Improving the Bacterial Recovery by Using Dithiothreitol with Aerobic and Anaerobic Broth in Biofilm-Related Prosthetic and Joint Infections.Adv Exp Med Biol. 2017;973:31-39.
Lovati AB, Bottagisio M, Moretti M. Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review. Stem Cells Int. 2016;2016:7276150.
Bottagisio M, Pellegata AF, Boschetti F, Ferroni M, Moretti M, Lovati AB. A new strategy for the decellularisation of large equine tendons as biocompatible tendon substitutes. Eur Cell Mater. 2016 Jul8;32:58-73.
Bottagisio M, Lovati AB. A review on animal models and treatments for the reconstruction of Achilles and flexor tendons. J Mater Sci Mater Med. 2017 Mar;28(3):45.
Pellegata AF, Bottagisio M, Boschetti F, Ferroni M, Bortolin M, Drago L, Lovati AB. Terminal sterilization of equine-derived decellularized tendons for clinical use. Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:43-49.
Bottagisio M, Lopa S, Granata V, Talò G, Bazzocchi C, Moretti M, Barbara Lovati A. Different combinations of growth factors for the tenogenic differentiation of bone marrow mesenchymal stem cells in monolayer culture and in fibrin-based three-dimensional constructs. Differentiation. 2017 May – Jun;95:44-53.