Laboratory of Biotechnological Applications
Director: Prof. Anna Brini
Prof. Anna Brini, Ph.D.
Anna Teresa Brini, researcher and adjunct professor of Pharmacology at the Università degli Studi di Milano, is Director of the Laboratory of Biotechnological Applications. She received her Master degree in Biological Sciences at the Università degli Studi di Milano and her PhD in Pharmacology and Toxicology. She spent several years abroad during her Phd at the National Cancer Institute in Frederick- MD USA and during her Postdoc at the National Institute of Health in Rockville-MD under the supervision of Prof. J-P Kinet, an immunologist dedicated to the IgE system. She is a researcher at the Department of Biomedical, Surgical and Dental Sciences and Adjunct Professor of Pharmacology at the Dental School. In the last ten years her main research interest focused on the features of Mesenchymal Stem/Stromal cells (MSCs), their applications in the musculoskeletal tissue regeneration and on their secretome as therapeutic agent. More recently she wanted to investigate bone tumors and, in collaboration with Prof. F. Latif of the Birmingham University, some epigenetic and genetic alterations have been found and they could have some prognostic implications. She is the Scientific Director of STaMeTec “ Staminali Mesenchimali per Terapie Cellulari” a Research Center of the Università degli Studi di Milano. She is author of more then 70 scientific papers in international peer-reviewed journals and her H Index is 21 (Scopus).
She is qualified as Associate Professor by National Academic Boards in both Pharmacology and Applied Biology. She is member of the National Society of Pharmacology and one of the founders and board members of the GISM “Gruppo Italiano Cellule Staminali Mesenchimali”.
Brini AT, Amodeo G, Ferreira LM, Milani A, Niada S, Moschetti G, Franchi S, Borsani E, Rodella LF, Panerai AE, Sacerdote P. Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain. Sci Rep. 2017 Aug 29;7(1):9904. doi: 10.1038/s41598-017-09487-5.
Coccè V, Farronato D, Brini AT, Masia C, Giannì AB, Piovani G, Sisto F, Alessandri G, Angiero F, Pessina A. Drug Loaded Gingival Mesenchymal Stromal Cells (GinPa-MSCs) Inhibit In Vitro Proliferation of Oral Squamous Cell Carcinoma. Sci Rep. 2017 Aug 24;7(1):9376. doi: 10.1038/s41598-017-09175-4.
Nigro EA, Brini AT, Yenagi VA, Ferreira LM, Achatz-Straussberger G, Ambrosi A, Sanvito F, Soprana E, van Anken E, Achatz G, Siccardi AG, Vangelista L. Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice. J Immunol. 2016 Oct 1;197(7):2583-8. doi: 10.4049/jimmunol.1601026.
Brini AT, Coccè V, Ferreira LM, Giannasi C, Cossellu G, Giannì AB, Angiero F, Bonomi A, Pascucci L, Falchetti ML, Ciusani E, Bondiolotti G, Sisto F, Alessandri G, Pessina A, Farronato G. Cell-mediated drug delivery by gingival interdental papilla mesenchymal stromal cells (GinPa-MSCs) loaded with paclitaxel. Expert Opin Drug Deliv. 2016 Jun;13(6):789-98. doi: 10.1517/17425247.2016.1167037.
Alholle A, Brini AT, Bauer J, Gharanei S, Niada S, Slater A, Gentle D, Maher ER, Jeys L, Grimer R, Sumathi VP, Latif F. Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas. Epigenetics. 2015;10(3):213-20. doi: 10.1080/15592294.2015.1006497.
Niada S, Ferreira LM, Arrigoni E, Addis A, Campagnol M, Broccaioli E, Brini AT. Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery. Stem Cell Res Ther. 2013;4(6):148. PubMed PMID: 24330736;
Gharanei S, Brini AT, Vaiyapuri S, Alholle A, Dallol A, Arrigoni E, Kishida T, Hiruma T, Avigad S, Grimer R, Maher ER, Latif F. RASSF2 methylation is a strong prognostic marker in younger age patients with Ewing sarcoma. Epigenetics. 2013 Sep;8(9):893-8. doi: 10.4161/epi.25617.
Sacerdote P, Niada S, Franchi S, Arrigoni E, Rossi A, Yenagi V, de Girolamo L, Panerai AE, Brini AT. Systemic administration of human adipose-derived stem cells reverts nociceptive hypersensitivity in an experimental model of neuropathy. Stem Cells Dev. 2013 Apr 15;22(8):1252-63. doi:10.1089/scd.2012.0398.
Quirici N, Scavullo C, de Girolamo L, Lopa S, Arrigoni E, Deliliers GL, Brini AT. Anti-L-NGFR and -CD34 monoclonal antibodies identify multipotent mesenchymal stem cells in human adipose tissue. Stem Cells Dev. 2010 Jun;19(6):915-25. doi: 10.1089/scd.2009.0408.
de Girolamo L, Lopa S, Arrigoni E, Sartori MF, Baruffaldi Preis FW, Brini AT. Human adipose-derived stem cells isolated from young and elderly women: their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation. Cytotherapy. 2009;11(6):793-803. doi: 10.3109/14653240903079393.