Laboratory of Biotechnological Applications – Niada, Stefania

Laboratory of Biotechnological Applications

Director: Prof. Anna Brini

Stefania Niada, Ph.D.


Stefania Niada received her Master’s Degree in Biology Applied to Research in Biomedicine in 2009 and her PhD in Pharmacological Sciences in 2014, both from University of Milan (Italy). During her PhD under the supervision of Prof. Brini and sponsored by IRCCS Galeazzi Orthopaedic Institute, her research activity was focused on exploring Mesenchymal Stem/Stromal cells (MSCs) features and their applications, especially for regenerative medicine. During her PostDoc in Prof. Brini’s lab, she continued her investigations on MSCs, focusing on their secretome as a therapeutic agent. At that time, she also started to work on bone cancer genetics. She was visiting PostDoc in Prof Latif’s lab (Institute of Cancer and Genomic Sciences, University of Birmingham, UK) where she undertook extensive training. She is currently working on both research topics.


Gualerzi A, Niada S, Giannasi C, Picciolini S, Morasso C, Vanna R, Rossella V, Masserini M, Bedoni M, Ciceri F, Bernardo ME, Brini AT, Gramatica F. Raman spectroscopy uncovers biochemical tissue-related features of extracellular vesicles from mesenchymal stromal cells. Sci Rep. 2017 Aug 29;7(1):9820. doi: 10.1038/s41598-017-10448-1.

Brini AT, Amodeo G, Ferreira LM, Milani A, Niada S, Moschetti G, Franchi S, Borsani E, Rodella LF, Panerai AE, Sacerdote P. Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain. Sci Rep. 2017 Aug 29;7(1):9904. doi: 10.1038/s41598-017-09487-5.

Niada S, Giannasi C, Ferreira LM, Milani A, Arrigoni E, Brini AT. 17β-estradiol differently affects osteogenic differentiation of mesenchymal stem/stromal cells from adipose tissue and bone marrow. Differentiation. 2016 Dec;92(5):291-297. doi: 10.1016/j.diff.2016.04.001. Epub 2016 Apr 14.

Ceci C, Niada S, Del Fabbro M, Lolato A, Taschieri S, Giannasi C, Brini AT. Does Freeze-Thawing Influence the Effects of Platelet Concentrates? An In Vitro Study on Human Adipose-Derived Stem Cells. J Craniofac Surg. 2016 Mar;27(2):398-404. doi: 10.1097/SCS.0000000000002428.

de Girolamo L, Niada S, Arrigoni E, Di Giancamillo A, Domeneghini C, Dadsetan M, Yaszemski MJ, Gastaldi D, Vena P, Taffetani M, Zerbi A, Sansone V, Peretti GM, Brini AT. Repair of osteochondral defects in the minipig model by OPF hydrogel loaded with adipose-derived mesenchymal stem cells. Regen Med. 2015;10(2):135-51. doi: 10.2217/rme.14.77.

Alholle A, Brini AT, Bauer J, Gharanei S, Niada S, Slater A, Gentle D, Maher ER, Jeys L, Grimer R, Sumathi VP, Latif F. Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas. Epigenetics. 2015;10(3):213-20. doi: 10.1080/15592294.2015.1006497.

Foudah D, Monfrini M, Donzelli E, Niada S, Brini AT, Orciani M, Tredici G, Miloso M. Expression of neural markers by undifferentiated mesenchymal-like stem cells from different sources. J Immunol Res. 2014;2014:987678. doi: 10.1155/2014/987678. Epub 2014 Mar 5.

Niada S*, Ferreira LM*, Arrigoni E, Addis A, Campagnol M, Broccaioli E, Brini AT. Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery. Stem Cell Res Ther. 2013;4(6):148.

Broccaioli E*, Niada S*, Rasperini G, Ferreira LM, Arrigoni E, Yenagi V, Brini AT. Mesenchymal Stem Cells from Bichat’s Fat Pad: In Vitro Comparison with Adipose-Derived Stem Cells from Subcutaneous Tissue. Biores Open Access. 2013 Apr;2(2):107-17. doi: 10.1089/biores.2012.0291.

Sacerdote P, Niada S, Franchi S, Arrigoni E, Rossi A, Yenagi V, de Girolamo L, Panerai AE, Brini AT. Systemic administration of human adipose-derived stem cells reverts nociceptive hypersensitivity in an experimental model of neuropathy. Stem Cells Dev. 2013 Apr 15;22(8):1252-63. doi: 10.1089/scd.2012.0398. Epub 2013 Jan 9.

*equal contributions