Carlotta Perucca Orfei received her Master Degree in Pharmacy in 2013 and the Doctoral degree (PhD) in Chemical and Pharmaceutical Sciences in 2017, both at the University of Pavia, Italy. Since 2014, she is a researcher at Orthopedic Biotechnology Laboratory and is involved in several research projects concerning Mesenchymal Stem/Stromal cells–based therapy and delivery in the orthopedic field. In 2016, she has been a visiting PhD student at the Andalusian Centre of Nanomedicine and Biotechnology-BIONAND under the supervision of Dr. Leonor Santos-Ruiz. Currently, her main interest, as a post-doc researcher, is the development of innovative therapeutic approaches for tendon healing.
Perucca Orfei C, de Girolamo L, Perteghella S, Stanco D, Chlapanidas T, Viganò M, Torre ML. Alginate beads as a vehicle for mesenchymal stem cells isolated from adipose tissue and tendon tissue: in vitro evaluation of a new approach or the treatment of tendinopathies Journal of Sports Traumatology, 31(1), 2014: 23-31
Stanco D, Viganò M, Perucca Orfei C, Di Giancamillo A, Thiebat G, Peretti G, de Girolamo L. In vitro characterization of stem progenitor cells from semitendinosus and gracilis tendons as a possible new tool for cell-based therapy for tendon disorders. Joints. 2015 Feb 13;2(4):159-68.
Stanco D, Viganò M, Perucca Orfei C, Di Giancamillo A, Lanfranchi L, de Girolamo L. Comparison of multi-differetiative potential of human tendon stem/progenitor cells and adipose-derived stem cells for muscoloskeletal cell-based therapy. Regen Med. 2015 Jan 7:1-15.
Zaffagnini S, Cucchiarini M, de Girolamo L, Angele P, Helder P, Rui LR, Henning M, Perucca Orfei C, Zellner J, Filardo G. Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspectives. Surgery of the Meniscus, 2016 DOI 10.1007/978-3-662-49188-1_58
Randelli P, Menon A, Ragone V, Creo P, Montrasio UA, Perucca Orfei C, Banfi G, Cabitza P, Tettamanti G, Anastasia L. Effects of the pulsed electromagnetic field PST® on human tendon stem cells: a controlled laboratory study. BMC Complement Altern Med. 2016 Aug 18;16:293.
Perucca Orfei C*, Lovati AB*, Viganò M, Stanco D, Bottagisio M, Di Giancamillo A, Setti S, de Girolamo L.Dose-Related and Time-Dependent Development of Collagenase-Induced Tendinopathy in Rats. PLoS One. 2016 Aug 22;11(8):e0161590.
Viganò M, Sansone V, d’Agostino MC, Romeo P, Perucca Orfei C, de Girolamo L. Mesenchymal stem cells as therapeutic target of biophysical stimulation for the treatment of musculoskeletal disorders. J Orthop Surg Res. 2016 Dec 16;11(1):163. Review
Viganò M *, Perucca-Orfei C*, Colombini A, Stanco D, Randelli P, Sansone V, de Girolamo L. Different culture conditions affect the growth of human tendon stem/progenitor cells (TSPCs) within a mixed tendon cells (TCs) population. J Exp Orthop. 2017 Dec;4(1):8
Fabrication of Innovative Silk/Alginate Microcarriers for Mesenchymal Stem Cell Delivery and Tissue Regeneration. Perteghella S*, Martella E*, de Girolamo L, Perucca Orfei C, Pierini M, Fumagalli V, Pintacuda DV, Chlapanidas T, Viganò M, Faragò S, Torre ML, Lucarelli E. Int J Mol Sci. 2017 Aug 23;18(9).
High levels of circulating type II collagen degradation marker (CTx-II) are associated with specific VDR polymorphisms in patients with adult vertebral osteochondrosis. Cauci S, Viganò M, de Girolamo L, De Luca P, Perucca Orfei C, Banfi G, Lombardi G, Brayda-Bruno M, Colombini A. Int J Mol Sci. 2017 Sep 29;18(10)