Zebrafish Lab – Mariotti, Massimo


Massimo Mariotti, biologist, is the director of the Zebrafish Laboratory of Bone Metabolism and Disease. He received his Master degree in Biological Sciences at the University of Milan, Italy in the 1996. He was a post-doc researcher in the Fishman’s Lab at Cardiovascular Research Center (CVRC) – Mass. General Hospital – Harvard Medical School (Boston, USA) where he was involved in research projects concerning the cardiovascular development in Danio rerio. From 2002 he is aggregate professor of General Pathology at the University of Milan where does research and teaching activity at the Medical School. From 2010 is the Director of Zebrafish Laboratory of Bone Metabolism and Disease. His main research interests are the physiological mechanisms of adult bone metabolism and turnover in Danio rerio. In addition, he created different zebrafish models of human bone diseases useful for pathophysiological studies and drug screening. He published several papers in international peer-reviewed journals.



Pasqualetti S, Banfi G, Mariotti M. Osteoblast and osteoclast behavior in zebrafish cultured scales. Cell Tissue Res. 2012 Oct;350(1):69-75.

Pasqualetti S, Banfi G, Mariotti M. The zebrafish scale as model to study the bone mineralization process. J Mol Histol. 2012 Oct;43(5): 589-95.

Pasqualetti S, Banfi G, Mariotti M. The effects of strontium on skeletal development in zebrafish embryo. J Trace Elem Med Biol. 2013 Jun 25.

Zennaro C, Mariotti M, Carraro M, Pasqualetti S, Corbelli A, Armelloni S, Li M, Ikehata M, Clai M, Artero M, Messa P, Boscutti G, Rastaldi MP. Podocyte developmental defects caused by adriamycin in zebrafish embryos and larvae: a novel model of glomerular damage. PLoS One. 2014 May 20;9(5):e98131.

Pasqualetti S, Congiu T., Banfi G, Mariotti M. Alendronate rescued osteoporotic phenotype in a model of glucocorticoid-induced osteoporosis in adult zebrafish scale. Int J Exp Pathol. 2015 Feb;96(1):11-20.

Mariotti M, Carnovali M, Banfi G. Danio rerio: the janus of the bone from embryo to scale. Clin Cases Miner Bone Metab. 2015 May-Aug;12(2):188-94.

Carnovali M, Ottria R, Pasqualetti S, Banfi G, Ciuffreda P, Mariotti M. Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease. Pharmacol Res. 2016 Feb;104:1-8.

Carnovali M, Banfi G, Mora S, Mariotti M. Tenofovir and bone: age-dependent effects in a zebrafish animal model. Antivir Ther. 2016 Apr 1.

Carnovali M, Luzi L, Banfi G, Mariotti M. Chronic hyperglycemia affects bone metabolism in adult zebrafish scale model. Endocrine. 2016 Dec;54(3):808-817.

Carnovali M, Banfi G, Mariotti M. The adult zebrafish as polyhedric model for skeletal studies. J Biol Regul Homeost Agents. 2016 Oct-Dec;30(4 Suppl 1):213-218.