Cell and Tissue Engineering Laboratory – Moretti, Matteo


Matteo Moretti is currently the Head of the Cell and Tissue Engineering Lab. He is also the director of the Regenerative Medicine Technologies Laboratory at EOC (Lugano, Switzerland) and he is a research affiliate at Harvard – MIT Division of Health Sciences and Technology, MIT (Cambridge, USA). He graduated in Biomedical Engineering at Politecnico di Milano and got his master degree in bioengineering at Trinity College, Dublin. After his PhD at Politecnico di Milano, in collaboration with prof. Ivan Martin at University Hospital Basel, he was awarded with a Postdoctoral Fellowship funded by MIT, at the Langer Lab, MIT (USA), under the supervision of prof. Lisa Freed. Within the interdisciplinary field of tissue engineering his main research interests lie within multiscale advanced cell culture technologies. In multiscale bioreactor systems from design to fully working prototypes, aimed at developing microfluidic and bioreactor technologies for up-scalable, automated platforms as a key to more viable advanced therapies. On application of different physico-chemical cues to engineered vascularized tissues, with concern to human primary in vitro 3D model systems aimed at translational applications and as novel tools for biology research. He is treasurer and Council member of the Tissue Engineering Regenerative Medicine International Society (TERMIS-EU) and acts as Expert Reviewer for various Governments and Institutions, amongst which EU-FP7/HORIZON2020, UK BBSRC, Cancer Research UK, Israel-US BSF, Hong Kong ITC, German BMBF, Netherlands ZonMw, and ETH Zurich. He holds a licensed patent and is co-founder of 2 biotech startups (SKE s.r.l. and CELLEC A.G.) focused on bioreactor technologies. He is author of more than 65 papers on international peer reviewed journals.


Talò G, Turrisi C, Arrigoni C, Recordati C, Gerges I, Tamplenizza M, Cappelluti A, Riboldi SA, Moretti M Industrialization of a perfusion bioreactor: prime example of a non-straightforward process. J Tissue Eng Regen Med. 2017 May 16.

Bersini S, Yazdi IK, Talò G, Shin SR, Moretti M*, Khademhosseini A*. Cell-microenvironment interactions and architectures in microvascular systems. Biotechnol Adv. 2016 Nov 1;34(6):1113-30. (* equally contrib. corr. auth.)

Arrigoni C, Bongio M, Talò G, Bersini S, Enomoto J, Fukuda J, Moretti M. Rational Design of Prevascularized Large 3D Tissue Constructs using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels. Adv Healthc Mater. 2016 Jul;5(13):1617-26.

Bongio M, Lopa S, Gilardi M, Bersini S, Moretti M. A 3D vascularized bone remodeling model combining osteoblasts and osteoclasts in a CaP nanoparticle-enriched matrix. Nanomedicine (Lond). 2016 May;11(9):1073-91

Bersini S, Gilardi M, Arrigoni C, Talò G, Zamai M, Zagra L, Caiolfa V, Moretti M. Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 2016 Jan;76:157-72

Jeon JS, Bersini S, Gilardi M, Dubini G, Charest JL, Moretti M*, Kamm RD*. Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. PNAS. 2015 Jan;112(1):214-9 (* equally contrib. corr. auth.)

Lopa S, Piraino F, Kemp RJ, Di Caro C, Lovati AB, Di Giancamillo A, Moroni L, Peretti GM, Rasponi M, Moretti M. Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniques. Biotechnol Bioeng. 2015 Jul;112(7):1457-71

Bersini S, Jeon JS, Dubini G, Arrigoni C, Chung S, Charest JL, Moretti M*, Kamm RD*. A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials. 2014 Mar;35(8):2454-61 (* equally contrib. corr. auth.)

Lopa S, Colombini A, Stanco D, de Girolamo L, Sansone V, Moretti M. Donor-matched mesenchymal stem cells from knee infrapatellar and subcutaneous adipose tissue of osteoarthritic donors display differential chondrogenic and osteogenic commitment. Eur Cell Mater. 2014 Apr 23;27:298-311.

Sadr N, Zhu M, Osaki T, Kakegawa T, Yang Y, Moretti M, Fukuda J, Khademhosseini A. SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures. Biomaterials. 2011 Oct;32(30):7479-90.