CELL AND TISSUE ENGINEERING LABORATORY
Director: Dr. Matteo Moretti
Talò Giuseppe, Ph.D.
Bio
Giuseppe Talò, engineer, works as a Research Fellow at the Cell and Tissue Engineering Lab, IRCCS Galeazzi Orthopaedic Institute (Milan – Italy) since 2008. In 2007, he graduated in Biomedical Engineering, with a thesis on the development of a dynamic bioreactor suitable to develop aortic valve constructs starting from decellularized human homografts in IRCCS Centro Cardiologico “Monzino”. He collaborated at the Politecnico of Milan – Department of Bioengineering (2007-2008). His main research activities are based on Tissue Engineering. Developing perfusion bioreactors equipped with pH and O2 sensors; biosensors for online monitoring permeability of 3D cultured tissue in bioreactors; bioreactors for the screening of the effects of complex biomechanical stimuli on engineered cartilage; works on vascularized bone tissue engineering; rapid prototyping and 3d printing.
Publications
Talò G, Turrisi C, Arrigoni C, Recordati C, Gerges I, Tamplenizza M, Cappelluti A, Riboldi SA, Moretti M. Industrialization of a perfusion bioreactor: Prime example of a non-straightforward process. J Tissue Eng Regen Med. 2017 May 16. doi: 10.1002/term.2480. [Epub ahead of print]
Bottagisio M, Lopa S, Granata V, Talò G, Bazzocchi C, Moretti M, Barbara Lovati A. Different combinations of growth factors for the tenogenic differentiation of bone marrow mesenchymal stem cells in monolayer culture and in fibrin-based three-dimensional constructs. Differentiation. 2017 May – Jun;95:44-53. doi: 0.1016/j.diff.2017.03.001. Epub 2017 Mar 16.
Bersini S, Yazdi IK, Talò G, Shin SR, Moretti M, Khademhosseini A. Cell-microenvironment interactions and architectures in microvascular systems. Biotechnol Adv. 2016 Nov 1;34(6):1113-30. doi: 10.1016/j.biotechadv.2016.07.002. Epub 2016 Jul 11. Review.
Mayer N, Lopa S, Talò G, Lovati AB, Pasdeloup M, Riboldi SA, Moretti M, Mallein-Gerin F. Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges. PLoS One. 2016 Sep 1;11(9):e0161479. doi: 10.1371/journal.pone.0161479. eCollection 2016.
Lovati AB, Lopa S, Recordati C, Talò G, Turrisi C, Bottagisio M, Losa M, Scanziani E, Moretti M. In Vivo Bone Formation Within Engineered Hydroxyapatite Scaffolds in a Sheep Model. Calcif Tissue Int. 2016 Aug;99(2):209-23. doi: 10.1007/s00223-016-0140-8. Epub 2016 Apr 13.
Arrigoni C, Bongio M, Talò G, Bersini S, Enomoto J, Fukuda J, Moretti M. Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels. Adv Healthc Mater. 2016 Jul;5(13):1617-26. doi: 10.1002/adhm.201500958. Epub 2016 May 18.172
Bersini, M. Gilardi, C. Arrigoni, G. Talò, M. Zamai, L. Zagra, V. Caiolfa, M. Moretti. Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials. 2015 Oct 24;76:157-172. doi: 10.1016/j.biomaterials.2015.10.057.
A.B. Lovati(*), E. Vianello(*), G. Talò, C. Recordati, E.Galliera, M. Broggini, M.Moretti: Biodegradable Microcarriers as cell delivery vehicle for in vivo transplantation and magnetic resonance monitoring – J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2 Suppl):S63-74
M.T. Raimondi, E. Bonacina, G.Candiani, M. Laganà, E. Rolando, G.Talò, D. Pezzoli, R. D’Anchise, R.Pietrabissa, M.Moretti: Comparative chondrogenesis of human cells in a 3D integrated experimental–computational mechanobiology model – Biomech Model Mechanobiol. 2011 Apr;10(2):259-68. Epub 2010 Jun 12.
Vismara,M. Soncini, G. Talo’, L.Dainese, A. Guarino, A.Redaelli, and G. B. Fiore: A Bioreactor with Compliance Monitoring for Heart Valve Grafts. Annals of Biomedical Engineering (2009), Ann Biomed Eng. 2010 Jan;38(1):100-8. Epub 2009 Sep 22.